We study the biology of microRNAs (miRNAs) which play important roles in gene regulation. To study the molecular mechanisms of miRNA pathway, we combine various methodologies including cell biological, biochemical, computational and biophysical techniques. The main focus of the lab has been on the mechanism of miRNA biogenesis. By identifying several key factors such as Drosha, we made major contributions to the current understanding of how miRNAs are created and processed in cells. We are now investigating the function and regulation of miRNAs in cancer and stem cells. This will be of critical importance in the efforts to eradicate cancer and harness stem cells by taking advantage of miRNA-mediated gene control.
Photos: Courtesy of Micheline Pelletier