RESEARCH ARTICLES

▪ H. H. Lee, Y. S. Kim, K. H. Kim, I. Heo, S. K. Kim, O. Kim, H. K. Kim, J. Y. Yoon, H. S. Kim, D. J. Kim, H. J. Yoon, S. J. Kim, B. G. Lee, H. K. Song, V. N. Kim, C. M. Park and S. W. Suh (2007) "Structural and functional insights into Dom34, a key component of No-Go mRNA decay" Molecular Cell 27(6):938-50   doi:10.1016/j.molcel.2007.07.019 (PDF, supplements)

▪ S. Y. Sohn, W. J. Bae, J. J. Kim, K. H. Yeom, V. N. Kim and Y. Cho (2007) "Crystal structure of human DGCR8 core" Nature Structural and Molecular Biology 14(9):847-53   doi:10.1038/nsmb1294 (PDF, supplements)

Y. K. Kim and V. N. Kim (2007) "Processing of intronic microRNAs" EMBO J. 26(3):775-83    doi:10.1038/sj.emboj.7601512 (PDF)

▪ J. T. Lee, S. S. Yu, V. N. Kim and S. Kim (2007) "Control of Splicing Efficiency by the Mouse Histone H2a Element in a Murine Leukemia Virus-based Retroviral Vector" Molecular Therapy 15(1):167-72   doi:10.1038/sj.mt.6300007 (PDF)

 

K. H. Yeom, Y. Lee, J. Han, M. R. Suh and V. N. Kim (2006) "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing" Nucleic Acids Research 34(16):4622-9    doi:10.1093/nar/gkl458  (PDF, supplements)

▪ S. J. Yim, Y. S. Lee, D. J. Chang, J. H. Han, H. Kim, H. Park, H. Jun, V. N. Kim and B. K. Kaang (2006) "Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation" J Neurochemistry 98(2):420-9 doi:10.1111/j.1471-4159.2006.03887.x    (PDF)

J. Han*, Y. Lee*, K. H. Yeom*, J. W. Nam, I. Heo, J. K. Rhee, S. Y. Sohn, Y. Cho, B. T. Zhang, and V. N. Kim (2006) "Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex" Cell 125(5):887-901    doi:10.1016/j.cell.2006.03.043     (PDF, supplements)  *equal contribution

Y. Lee*, I. Hur*, S. Y. Park*, Y. K. Kim, M. R. Suh and V. N. Kim(2006) "The role of PACT in the RNA silencing pathway" EMBO J. 25(3):522-32 doi:10.1038/sj.emboj.7600942    (PDF)  *equal contribution

 

J. W. Nam, K. R. Shin, J. Han, Y. Lee, and V. N. Kim, B. T. Zhang (2005) "Human microRNA prediction through a probabilistic co-learning model of sequence and structure" Nucleic Acids Research 33(11):3570-81   doi:10.1093/nar/gki668    (PDF, supplements 1 2)

▪ K. Lee, K. Jeon, J. M. Kim, V. N. Kim, D. H. Choi, S. U. Kim and S. Kim (2005) "Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus" Glia 51(1):1-12. doi:10.1002/glia.20179    (PDF)

  

J. Han*, Y. Lee*, K. H. Yeom, Y. K. Kim, H. Jin and V. N. Kim (2004) "The Drosha-DGCR8 complex in primary microRNA processing" Genes & Development 18(24):3016-27   doi:10.1101/gad.1262504  (PDF, supplements)   *equal contribution

Y. Lee, M. Kim, J. Han, K. H. Yeom, S. Lee, S. H. Baek, and V. N. Kim (2004) "MicroRNA genes are transcribed by RNA polymerase II" EMBO J. 23(20):4051-60   doi:10.1038/sj.emboj.7600385   (PDF)

M. R. Suh, Y. Lee, J. Y. Kim, S. K. Kim, S. H. Moon, J. Y. Lee, K. Y. Cha, H. M. Chung, H. S. Yoon, S. Y. Moon, V. N. Kim and K. S. Kim (2004) "Human embryonic stem cells express a unique set of microRNAs" Developmental Biology 270(2):488-98 doi:10.1016/j.ydbio.2004.02.019   (PDF)

 

Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, V. N. Kim (2003) "The nuclear RNase III Drosha initiates microRNA processing" Nature 425(6956):415-9   doi:10.1038/nature01957   (PDF, supplements)

 

Y. Lee, K. Jeon, J. T. Lee, S. Kim and V. N. Kim (2002) "MicroRNA maturation: stepwise processing and subcellular localization" EMBO J. 21(17):4663-70   doi:10.1093/emboj/cdf476   (PDF)

 

  

REVIEWS

 ▪ V. N. Kim (2008) "Sorting out small RNAs" Cell 133:25-26    doi:10.1016/j.cell.2008.03.015    (PDF)

  V. N. Kim (2006) "Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes" Genes & Developement 20(15):1993-7    doi:10.1101/gad.1456106    (PDF)

 V. N. Kim and J. W. Nam (2006) "Genomics of microRNA" Trends in Genetics 22(3):165-73   doi:10.1016/j.tig.2006.01.003   (PDF)

  V. N. Kim (2005) "MicroRNA biogenesis: coordinated cropping and dicing" Nature Reviews. Molecular Cell Biology 6(5):376-85   doi:10.1038/nrm1644   (PDF)

V. N. Kim (2005) "Small RNAs: classification, biogenesis, and function" Molecules and Cells 19(1):1-15   (PDF)

  V. N. Kim (2004) "MicroRNA precursors in motion: exportin-5 mediates their nuclear export" Trends in Cell Biology 14(4):156-9   doi:10.1016/j.tcb.2004.02.006   (PDF)

V. N. Kim (2003) "RNA interference in functional genomics and medicine" J Korean Medical Science 18(3):309-18   (PDF)

 

BOOK CHAPTERS

  Y. Lee and V. N. Kim (2007) "In vitro and in vivo assays for the activity of drosha complex" Methods in Enzymology 427:87-106   doi:10.1016/S0076-6879(07)27005-3 

  Y. Lee, J. Han, K. H. Yeom, H. Jin and V. N. Kim (2006) "Drosha in primary microRNA processing" Cold Spring Harbor Symposia on Quantative Biology (2006) 71:51-7    doi:10.1101/sqb.2006.71.041

  Y. Lee and V. N. Kim (2005) "Preparation and analysis of Drosha" Methods in Molecular Biology 309:17-28

 

PATENTS

  The inhibition method of microRNA

  The recombinant primary microRNA molecule for RNA interference