RNAs play a pivotal role in development and pathology as they stand at the core of gene regulation. In Narry Kim’s lab, we work on microRNA, RNA modification and RNA-binding proteins to better understand RNA-mediated gene regulation. Applying biochemical and molecular biological tools, as well as genetic, biophysical, and computational approaches, we try to uncover the function and mechanism of RNAs and RNA-binding proteins in stem cells, cancer, neuronal system and viruses.
microRNA: The tiny regulators with big roles
microRNAs are small noncoding RNAs involved in virtually all functional aspects of cellular function and developmental control such as cell differentiation, proliferation, death, embryogenesis, energy metabolism, and antiviral defense. Tight control of microRNAs is critical for normal functioning of cells, and dysregulation of microRNAs is often responsible for various human diseases. In Narry Kim’s lab, we made significant contributions to the current understanding of how microRNAs are created and processed by elucidating the mechanism of microRNA biogenesis and identifying several key factors in the biogenesis pathway, including DROSHA. We have also been investigating the function and regulation of microRNAs in cancer and stem cells in hopes that our studies will provide new opportunities for cancer treatment and stem cell engineering.
RNA modification: Sometimes, a tail can wag the dog
RNA modifications at the 3’ end determine the function and fate of the RNA. Detecting and analyzing such modifications is thus crucial in our understanding of RNA-mediated gene regulation. Previously, we found that microRNAs are uridylated or adenylated at the 3’ end and that these the 3’ tails regulate the biogenesis and stability of the microRNAs. More recently, we developed a technique called TAIL-seq that allows the genomic scale investigation of mRNA tails. Using this new tool, we are studying the function of mRNA tails in the context of development and human diseases.
RNA binding proteins: Dear partners of RNA
RNAs are never alone but form a selective complex of RNA binding proteins that dictate the particular stage of the RNA life cycle. Narry Kim’s lab is developing new tools to investigate the RNA-protein network, with the state-of-the-art proteomic facilities. Untangling this complex network will provide a more comprehensive understanding of the functions and mechanisms of RNAs in post-transcriptional gene regulation.
Welcome to RNA world
We welcome postdoc/student applications from all around the world and all areas of biology, in particular proteomics, bioinformatics, structural biology, and molecular cell biology. For more information and inquiries, please email us at narrykim at snu dot ac dot kr.
What's new on the Lab
Mihye started a new position as assistant professor at Soonchunhyang University. (2017)
Human Genome Organisation Chen Award. (2017)
Anh started a new position as assistant professor at Hong Kong University of Science and Technology. (2016)
Yoosik started a new position as assistant professor at Korea Advanced Institute of Science and Technology. (2016)
A video abstract of our recent DROSHA structure paper. (2016)
Young-Kook started a new position as assistant professor at Chonnam National University. (2015)
Elected as a foreign associate of National Academy of Sciences of the U.S.A. (2014)